Whithin the critique literature scope there are two standpoints as regards Machiavellian Cosmos: On one hand the traditional standpoint embodied by Leo Straus that has belittled the impact of the forces of nature; whereas on the other hand the standpoint headed by Gennaro Sasso, Miguel Angel Granada y Anthony Parel has interpreted the Machiavellian text concerning the debate between neoplatonics and neoaristotelians The Machiavelli´s overuse of a cosmological schema- wherein the life of the politic bodies is explained through an adequate (...) knowledge of the laws of the natural world-is argued in this paper as from the interpretation of the oblivione delle cose concept in D., II, V and D., I, LVI. (shrink)

Abstract: The Pull Bayesian Significance Test (FBST) for precise hy- potheses is applied to a Multivariate Normal Structure (MNS) model. In the FBST we compute the evidence against the precise hypothesis. This evi- dence is the probability of the Highest Relative Surprise Set (HRSS) tangent to the sub-manifold (of the parameter space) that defines the null hypothesis. The MNS model we present appears when testing equivalence conditions for genetic expression measurements, using micro-array technology.

This article describes the Full Bayesian Significance Test for the problem of separate hypotheses. Numerical experiments are performed for the Gompertz vs. Weibull life span test.

Much forensic inference based upon DNA evidence is made assuming Hardy-Weinberg Equilibrium (HWE) for the genetic loci being used. Several statistical tests to detect and measure deviation from HWE have been devised, and their limitations become more obvious when testing for deviation within multiallelic DNA loci. The most popular methods-Chi-square and Likelihood-ratio tests-are based on asymptotic results and cannot guarantee a good performance in the presence of low frequency genotypes. Since the parameter space dimension increases at a quadratic rate on (...) the number of alleles, some authors suggest applying sequential methods, where the multiallelic case is reformulated as a sequence of “biallelic” tests. However, in this approach it is not obvious how to assess the general evidence of the original hypothesis; nor is it clear how to establish the significance level for its acceptance/rejection. In this work, we introduce a straightforward method for the multiallelic HWE test, which overcomes the aforementioned issues of sequential methods. The core theory for the proposed method is given by the Full Bayesian Significance Test (FBST), an intuitive Bayesian approach which does not assign positive probabilities to zero measure sets when testing sharp hypotheses. We compare FBST performance to Chi-square, Likelihood-ratio and Markov chain tests, in three numerical experiments. The results suggest that FBST is a robust and high performance method for the HWE test, even in the presence of several alleles and small sample sizes. (shrink)

Intentional sampling methods are non-probabilistic procedures that select a group of individuals for a sample with the purpose of meeting specific prescribed criteria. Intentional sampling methods are intended for exploratory research or pilot studies where tight budget constraints preclude the use of traditional randomized representative sampling. The possibility of subsequently generalize statistically from such deterministic samples to the general population has been the issue of long standing arguments and debates. Nevertheless, the intentional sampling techniques developed in this paper explore pragmatic (...) strategies for overcoming some of the real or perceived shortcomings and limitations of intentional sampling in practical applications. (shrink)

Gene clustering is a useful exploratory technique to group together genes with similar expression levels under distinct cell cycle phases or distinct conditions. It helps the biologist to identify potentially meaningful relationships between genes. In this study, we propose a clustering method based on multivariate normal mixture models, where the number of clusters is predicted via sequential hypothesis tests: at each step, the method considers a mixture model of m components (m = 2 in the first step) and tests if (...) in fact it should be m - 1. If the hypothesis is rejected, m is increased and a new test is carried out. The method continues (increasing m) until the hypothesis is accepted. The theoretical core of the method is the full Bayesian significance test, an intuitive Bayesian approach, which needs no model complexity penalization nor positive probabilities for sharp hypotheses. Numerical experiments were based on a cDNA microarray dataset consisting of expression levels of 205 genes belonging to four functional categories, for 10 distinct strains of Saccharomyces cerevisiae. To analyze the method’s sensitivity to data dimension, we performed principal components analysis on the original dataset and predicted the number of classes using 2 to 10 principal components. Compared to Mclust (model-based clustering), our method shows more consistent results. (shrink)

Walter Benjamin fala da experiência como sendo o tipo de sabedoria que resulta do encontro de práticas individuais com o horizonte de sentido fornecido pela vida comunitária. Mas esse encontro tem se tornado mais difícil a partir do desenvolvimento da sociedade capitalista moderna. As novas dinâmicas de trabalho, somadas ao ritmo acelerado da vida urbana, favorecem o isolamento dos indivíduos e deturpam sua capacidade de filtrar, significativamente, os eventos que se acumulam no cotidiano. Muitas coisas acontecem, mas muito pouco permanece (...) desses acontecimentos. A experiência dá lugar, assim, à mera vivência. Diferentemente da experiência, que se articula a partir do fundo significativo de uma comunidade e se torna significativa em relação a ela, a vivência se constitui como um momento privado. A vivência não conecta os indivíduos à vida da comunidade, à tradição, e nisso reside sua pobreza. Pobreza de experiência é, portanto, pobreza cultural, carência de perspectivas mais amplas que possam apoiar uma avaliação significativa das vivências; em suma, incapacidade de aprender. Diante desse contexto, o presente ensaio busca enfatizar o impacto negativo da pobreza de experiência à constituição da subjetividade do indivíduo contemporâneo e assinalar a possibilidade de fazer frente a esse quadro de empobrecimento a partir de uma ideia de educação voltada à formação integral, que, mesmo diante do apelo crescente do conhecimento técnico-científico especializado, não abra mão do ensino das humanidades. Nessa linha, defende-se a tese de que as disciplinas de formação humanística, como Artes, Literatura, Filosofia, cumprem um papel de destaque no desenvolvimento das condições necessárias à realização de experiências, no sentido específico descrito por Benjamin. O ensaio, de cunho bibliográfico-hermenêutico, se apresenta como uma contribuição para pensar nos atuais desafios educacionais. Palavras-chave: Experiência. Pobreza de experiência. Walter Benjamin. Educação. Educação humanística. (shrink)

El viernes 01 de julio de 2022 se realizó, en el edificio Sergio Karakachoff de la UNLP, la presentación de los dos volúmenes de la "Antología comentada" de la obra de José Sazbón compilados por Alberto Pérez y Daniel Lvovich. La antología reúne el trabajo realizado durante décadas por el intelectual argentino José Sazbón, quien fuera profesor e investigador de la Facultad de Humanidades y Ciencias de la Educación y el primer Director de la Maestría en Historia y Memoria. (...) Recopilamos aquí las intervenciones de Fernanda Tocho (Secretaria Académica de la Maestría en Historia y Memoria), Mariana Canavese (UBA-CONICET), María Belforte (UBA-CONICET), Marcelo Starcenbaum (UNLP-CONICET), quienes oficiaron de presentadores de la antología, junto a sus compiladores, Daniel Lvovich (UNGS) y Alberto Pérez (UNLP), acompañados además por Carlos Gazzera (Director de Eduvim) y Ayelén Sidún (Decana de la Facultad de Periodismo y Comunicación Social). (shrink)

t Intentional sampling methods are non-randomized procedures that select a group of individuals for a sample with the purpose of meeting specific prescribed criteria. In this paper we extend previous works related to intentional sampling, and address the problem of sequential allocation for clinical trials with few patients. Roughly speaking, patients are enrolled sequentially, according to the order in which they start the treatment at the clinic or hospital. The allocation problem consists in assigning each new patient to one, and (...) only one, of the alternative treatment arms. The main requisite is that the profiles in the alternative arms remain similar with respect to some relevant patients’ attributes (age, gender, disease, symptom severity and others). We perform numerical experiments based on a real case study and discuss how to conveniently set up perturbation parameters, in order to yield a suitable balance between optimality – the similarity among the relative frequencies of patients in the several categories for both arms, and decoupling – the absence of a tendency to allocate each pair of patients consistently to the same arm. (shrink)

The Full Bayesian Significance Test (FBST) for precise hypotheses is presented, with some applications relevant to reliability theory. The FBST is an alternative to significance tests or, equivalently, to p-ualue.s. In the FBST we compute the evidence of the precise hypothesis. This evidence is the probability of the complement of a credible set "tangent" to the sub-manifold (of the para,rreter space) that defines the null hypothesis. We use the FBST in an application requiring a quality control of used components, based (...) on remaining life statistics. (shrink)

This article presents a two level hierarchical forecasting model developed in a consulting project for a Brazilian magazine publishing company. The first level uses a VARMA model and considers econometric variables. The second level takes into account qualitative aspects of each publication issue, and is based on polynomial networks generated by Genetic Programming (GP).

Clearing algorithms are at the core of modern payment systems, facilitating the settling of multilateral credit messages with (near) minimum transfers of currency. Traditional clearing procedures use batch processing based on MILP - mixed-integer linear programming algorithms. The MILP approach demands intensive computational resources; moreover, it is also vulnerable to operational risks generated by possible defaults during the inter-batch period. This paper presents TORC3 - the Token-Ring Clearing Algorithm for Currency Circulation. In contrast to the MILP approach, TORC3 is a (...) real time heuristic procedure, demanding modest computational resources, and able to completely shield the clearing operation against the participating agents’ risk of default. (shrink)

This article gives a conceptual review of the e-value, ev(H|X) – the epistemic value of hypothesis H given observations X. This statistical significance measure was developed in order to allow logically coherent and consistent tests of hypotheses, including sharp or precise hypotheses, via the Full Bayesian Significance Test (FBST). Arguments of analysis allow a full characterization of this statistical test by its logical or compositional properties, showing a mutual complementarity between results of mathematical statistics and the logical desiderata lying at (...) the foundations of this theory. (shrink)

To the extent that antibiotic resistance (ABR) is accelerated by antibiotic consumption and that it represents a serious public health emergency, it is imperative to drastically reduce antibiotic consumption, particularly in high‐income countries. I present the problem of ABR as an instance of the collective action problem known as ‘tragedy of the commons’. I propose that there is a strong ethical justification for taxing certain uses of antibiotics, namely when antibiotics are required to treat minor and self‐limiting infections, such as (...) respiratory tract infections, in otherwise healthy individuals. Taxation would allow a reduction in consumption (given certain behavioural economics assumptions) and/or ensure that individuals internalize or compensate for their contribution to the erosion of the common good of antibiotic effectiveness. I suggest that revenue from the tax could be used to fund conservation and innovation strategies. Taxation might be a coercive policy, especially for certain individuals, but the ethical case for coercive policies is very strong when the good to be preserved is important enough and when they force individuals to do something they have a moral obligation to do anyway. I argue that, in the case of mild and self‐limiting infections, individuals have a moral duty of easy rescue and a moral duty of fairness to make their contribution to the preservation of the common good of antibiotic effectiveness by foregoing antibiotics. I also suggest that taxing antibiotics in such cases is an all things considered ethically justified policy even if it would introduce inequalities in access to healthcare. (shrink)

Coll clearly advocates the Aristotelian notion that "moral principles are ultimately realized only in specific acts which human beings choose to carry out." He cites Washington, Lincoln, and Churchill as examples of leaders whose moral wisdom in political reasoning led to a statecraft explicitly derived from prudence.

This paper deals with structures ${\langle{\bf T}, I\rangle}$ in which T is a tree and I is a function assigning each moment a partition of the set of histories passing through it. The function I is called indistinguishability and generalizes the notion of undividedness. Belnap’s choices are particular indistinguishability functions. Structures ${\langle{\bf T}, I\rangle}$ provide a semantics for a language ${\mathcal{L}}$ with tense and modal operators. The first part of the paper investigates the set-theoretical properties of the set of indistinguishability (...) classes, which has a tree structure. The significant relations between this tree and T are established within a general theory of trees. The aim of second part is testing the expressive power of the language ${\mathcal{L}}$ . The natural environment for this kind of investigations is Belnap’s seeing to it that (stit). It will be proved that the hybrid extension of ${\mathcal{L}}$ (with a simultaneity operator) is suitable for expressing stit concepts in a purely temporal language. (shrink)

We argue that we should provide extra payment not only for extra time worked but also for the extra risks healthcare workers (and those working in healthcare settings) incur while caring for COVID‐19 patients—and more generally when caring for patients poses them at significantly higher risks than normal. We argue that the extra payment is warranted regardless of whether healthcare workers have a professional obligation to provide such risky healthcare. Payment for risk would meet four essential ethical requirements. First, assuming (...) healthcare workers do not have a professional obligation to take on themselves the risks, payments in the form of incentives would preserve autonomy in deciding what risks to take on oneself. Second, even assuming that healthcare workers do have a professional obligation to take on themselves the risks, payments for risk would create fair working conditions by avoiding exploitation. Third, payments for risk would make it more likely that public healthcare systems can discharge their institutional responsibility to provide healthcare in circumstances where healthcare workers may otherwise (perhaps legitimately) opt out. Fourth, payments for risk would guarantee an efficient healthcare system in pandemic situations. Finally, we address two likely objections that some might raise against our proposal, particularly with regard to incentives, namely that such payments or incentives can themselves be coercive and that they represent a form of undue inducement. (shrink)

This article presents the first comprehensive study of Syriac rhetoric in late antiquity. It builds on existing scholarship on the Syrians’ engagement with Graeco-Roman paideia and Christian rhetoric, but it also goes further in that it draws attention to the Syrians’ participation in Near Eastern rhetorical traditions (mainly transmitted through Aramaic) and in the rhetoric of the Hebrew Bible, which was translated into Syriac without Greek intermediaries. At the same time, this article demonstrates that Syriac rhetoric flourished in distinctive and (...) original ways: It developed its own literary genres (with a strong predilection for poetry and a sensibility for gendered voices), performative settings (including the liturgy and the school), and thematic domains (notably Scriptural exegesis and religious controversy). It is especially remarkable that an elaborate “meta-rhetorical” reflection flourished in Syriac, as it first emerged in the work by Antony of Tagrit in the ninth century and in the broader context of late antique and Byzantine Aristotelianism. This comprehensive survey and its conceptual systematisation are designed to facilitate further research on Syriac rhetoric both during late antiquity and in later centuries, when the Syrians’ interaction with Arabic rhetoric came to play an increasingly influential role.Syriac words are given in a simplified transcription. For consonants, the standard system in use for Semitic languages is followed; spirantisation of b g k p t is marked by v gh kh f th respectively. East Syrian vocalisation is generally adopted unless the words are quoted from a West Syrian author; vowel length is not marked, with the exception of a/ā and e/ē in Eastern Syriac. (shrink)

We discuss whether and under what conditions people should be allowed to choose which COVID-19 vaccine to receive on the basis of personal ethical views. The problem arises primarily with regard to some religious groups’ concerns about the connection between certain COVID-19 vaccines and abortion. Vaccines currently approved in Western countries make use of foetal cell lines obtained from aborted foetuses either at the testing stage or at the development stage. The Catholic Church’s position is that, if there are alternatives, (...) Catholic people have a moral obligation to request the vaccine whose link with abortion is more remote, which at present means that they should refuse the Oxford/AstraZeneca vaccine. We argue that any consideration regarding free choice of the vaccine should apply to religious and non-religious claims alike, in order to avoid religion-based discrimination. However, we also argue that, in a context of limited availability, considering the significant differences in costs and effectiveness profile of the vaccines available, people should only be allowed to choose the preferred vaccine if: 1) this does not risk compromising vaccination strategies; and 2) they internalize any additional cost that their choice might entail. The State should only subsidize the vaccine that is more cost-effective for any demographic group from the point of view of public health strategies. (shrink)

One is often told that sentences expressing or reporting mental states endowed with intentionality—the feature of being “directed upon” an object that some mental states possess—contain contexts that both prevent those sentences to be existentially generalized and are filled by referentially opaque occurrences of singular terms. Failure of existential generalization and referential opacity have been traditionally said to be the basic characterizations of intentionality from a linguistic point of view. I will call those contexts directional contexts. In what follows, I (...) will argue that this traditional conception is incorrect. First, the above characterizations do not provide both necessary and jointly sufficient conditions for directional contexts. Appearances notwithstanding, these characterizations are not the adequate linguistic counterparts of two elements folk-psychologically featuring intentionality, namely existence-independence and the possible apparent aspectual character of the intentional object, the target of a mental state endowed with intentionality. Indeed, they do not retain the prima facie ontological commitment to intentional objects the above elements contain. I will replace failure of existential generalization and referential opacity with other linguistic factors, namely success of mere existentially unloaded particular quantification and pseudo-opacity. I will contend that they provide both necessary and jointly sufficient conditions for directional contexts, and claim that these factors are the adequate counterparts of the above folk-psychological elements, precisely because they retain the prima facie ontological commitment to intentionalia those elements possess. (shrink)

In this paper we clarify some issues related to our previous article ‘After-birth abortion: why should the baby live?’.

The range of opportunities people enjoy in life largely depends on social, biological, and genetic factors for which individuals are not responsible. Philosophical debates about equality of opportunities have focussed mainly on addressing social determinants of inequalities. However, the introduction of human bioenhancement should make us reconsider what our commitment to equality entails. We propose a way of improving morally relevant equality that is centred on what we consider a fair distribution of bioenhancements. In the first part, we identify three (...) main positions in the debate on bioenhancement and equality, and we show how each of them fails to meet the demands of a serious commitment to equality. In the second part, we formulate a new proposal that we think better promotes equality of opportunities: people from disadvantaged socio-economic backgrounds should be given access to bioenhancements while people from privileged socio-economic background should be prohibited from using them. We argue that those who are concerned about the inequality implications of bioenhancement should embrace this solution, rather than reject bioenhancement. (shrink)

In Scepticism, Freedom and Autonomy, Araujo argues against this interpretation, asserting that we retain control over our opinions only through selective ...

Volume 20, Issue 9, September 2020, Page 62-65.

Les Cahiers noirs de Martin Heidegger ont suscité des réactions si divergentes qu’il n’est pas illégitime de s’interroger sur la cause de cette plurivocité. Est-il possible qu’une série de textes produise des réactions si discordantes – de la minimisation à l’exaspération, du sarcasme à la caricature, du scandale à l’excommunication? Il est opportun de chercher dans les Cahiers noirs les racines de cette fragmentation. Cet article soutenir la thèse selon laquelle la structure et les contenus mêmes des Cahiers noirs porteraient (...) en eux une sorte de double contrainte entre le dessin antimétaphysique et la « rechute » dans une métaphysique puissance deux : une contradiction interne à la trame des Cahiers noirs, qui produit deux figures de pensée incompatibles entre elles mais qui représente le contenu philosophique le plus précieux de ces textes. (shrink)

This book symposium comprises a précis of Nuno Venturinha’s Description of Situations: An Essay in Contextualist Epistemology together with four critical commentaries on different aspects of the book by Marcelo Carvalho, João Vergílio Gallerani Cuter, Marcos Silva and Darlei Dall’Agnol, and the author’s replies.

Cultural evolution researchers use transmission chain experiments to investigate which content is more likely to survive when transmitted from one individual to another. These experiments resemble oral storytelling, wherein individuals need to understand, memorize, and reproduce the content. However, prominent contemporary forms of cultural transmission—think an online sharing—only involve the willingness to transmit the content. Here I present two fully preregistered online experiments that explicitly investigated the differences between these two modalities of transmission. The first experiment (_N_ = 1,080 participants) (...) examined whether negative content, information eliciting disgust, and threat-related information were better transmitted than their neutral counterpart in a traditional transmission chain setup. The second experiment (_N_ = 1,200 participants) used the same material, but participants were asked whether or not they would share the content in two conditions: in a large anonymous social network or with their friends, in their favorite social network. Negative content was both better transmitted in transmission chain experiments and shared more than its neutral counterpart. Threat-related information was successful in transmission chain experiments but not when sharing, and finally, information eliciting disgust was not advantaged in either. Overall, the results present a composite picture, suggesting that the interactions between the specific content and the medium of transmission are important and, possibly, that content biases are stronger when memorization and reproduction are involved in the transmission—as in oral transmission—than when they are not—as in online sharing. Negative content seems to be reliably favored in both modalities of transmission. (shrink)

Últimamente se viene hablando mucho de “guerra cultural” si bien pocas veces se concreta su significado. Tiene que ver con la batalla por el relato, pero no se limita a este campo. En todo caso, conviene diferenciar este concepto del legítimo debate e intercambio de ideas en pos de la mejora social. Nos encontraríamos por el contrario más cerca de la guerra híbrida, psicológica, cognitiva y el arte de la propaganda llevados a cabo por unos Estados contra otros, pero también (...) por determinados agentes con poder suficiente para imponer la cultura que les interesa y acabar con la del contrario. (shrink)

Este artículo es una respuesta a la crítica de Noé Expósito Ropero —que se basa en gran medida en la visión de Javier San Martín— a mi interpretación de la filosofía de José Ortega y Gasset. El resultado del argumento de Expósito Ropero es que Ortega es más fenomenólogo de lo que yo considero, que me equivoco al pen-sar que existen los “objetos reales” más allá de los objetos intencionales de Edmund Husserl, y que ningún objeto inanimado puede ser tratado (...) como un “yo”. Como réplica, respondo a cada una de estas acusaciones.This article is a response to Noé Expósito Ropero’s critique—which draws heavily on the views of Javier San Martín—of my interpretation of the philosophy of José Ortega y Gasset. The upshot of Expósito Ropero’s argument is that Ortega is more of a phenomenologist than I realize, that I am wrong to think there is any such thing as “real objects” beyond Edmund Husserl’s intentional objects, and that no inanimate object can be treated as an “I.” In response, I answer each of these charges. (shrink)

El objetivo del presente trabajo es explicar la relación entre las nociones de discurso y acción en un marco pragmático trascendental. El trabajo comienza con una presentación de la primera noción y de la idea de pretensión de validez. Luego son examinadas algunas objeciones a la justificación última de la ética, formulada por Apel. La conclusión es que es posible una respuesta a esas objeciones mediante la diferenciación entre dos niveles de la relación entre discurso y acción: un nivel fáctico (...) y uno trascendental. The aim of this paper is to explain the relation between the notions of discourse and action in a transcendental-pragmatic frame. The paper begins with a presentation of the first notion and the idea of validity claim. After that, some objections to Apel's ultimate justifications of ethic are examined. The conclusion is that an answer to these objections is possible throw the difference between two levels of the relation between discourse and action: a real level and a transcendental one. (shrink)

A careful observation of the phenomenon of human life allows us to understand that from the beginning of the human life cycle until its destruction, the existence of each subject is deeply marked b...